RUQ pain different from wound pain. What inv will you do immediately?
a. Coagulation profile
b. LFT
c. Liver US
d. MRCP
e. None
answer: B
Presentation
- HELLP syndrome is a serious form of pre-eclampsia and patients may present at any time in the last half of pregnancy.
 - One third of women with HELLP syndrome present shortly after delivery.
 - Symptoms of HELLP syndrome are usually nonspecific.
 - Initially, women may report nonspecific symptoms including malaise, fatigue, right upper quadrant or epigastric pain, nausea, vomiting, or flu-like symptoms.
 - Hepatomegaly can occur.
 - Some women may have easy bruising/purpura.
 - On examination, oedema, hypertension and proteinuria are present.
 - Tenderness over the liver can occur.
 
Investigations
- There needs to be a high index of clinical suspicion in order to avoid diagnostic delay and improve outcome.
 - Haemolysis with fragmented red cells on the blood film
 - Raised LDH >600 IU/L with a raised bilirubin.
 - Liver enzymes are raised with an AST or ALT level of >70 IU/L.
 - Levels of AST or ALT >150 IU/L are associated with increased maternal morbidity and mortality.